Methyl iodide → HCID 21439984, compound

Participants

Reaction Steps

A mixture of ethyl 2-[3-chloro-4-(N-thiazol-2-ylamino)phenyl]acetate (8.9 g), methyl iodide (44 ml) and ethanol (44 ml) is heated at 50°-55° C for 42 hours with stirring. The ethanol and methyl iodide are evaporated and the residue is washed with ether and kept at room temperature to give a precipitate. The precipitate is washed with ethyl acetate and cold acetone successively and recrystallized from acetone to give 3-methyl-2-[2-chloro-4-(ethoxycarbonylmethyl)anilino]-thiazolium iodide (6.6 g) melting at 147°-148° C.

Provenance & Evidence