反应详情

420 ml of the (S)-3-(4-hydroxyphenyl)-2-methoxypropionic acid solution from above are treated with stirring with a solution of 16.32 g of sodium acetate in 136 ml of methanol. After addition of seed crystals, the mixture is stirred for 12 h at room temperature. The precipitated product is filtered off and the filter cake is washed twice with 20 ml each of MIBK. The product is dried in vacuo at 50° C. in the course of 12 h. 30.2 g (34.8%) of sodium (S)-3-(4-hydroxyphenyl)-2-methoxypropionate are obtained. Optical purity ee=95-97%. Chemical purity >99%.

1. additionAfter addition of seed crystals
2. filtrationThe precipitated product is filtered off
3. washthe filter cake is washed twice with 20 ml each of MIBK
4. customThe product is dried in vacuo at 50° C. in the course of 12 h