反应详情

温度

185 °C

A mixture of methyl 8-methylsulfonyl-8-methoxycarbonyl-12-acetoxy-13-(3-trifluoromethylphenoxy)tridecanoate (5.82 g., 0.01 mole), sodium chloride (0.59 g., 0.01 mole), dimethylsulfoxide (8 ml.), and water (0.2 ml.) is heated in an oil bath at 185° C. for 10 hours under nitrogen. The reaction mixture is then concentrated in vacuo on a steam bath. The dark-colored residue is diluted with water, acidified with 6N hydrochloric acid, and extracted with ether. The ether extracts are washed with water, dried with anhydrous magensium sulfate, and concentrated in vacuo to give the title compound (9.90 g., 0.019 mole, 94%).

1. concentrationThe reaction mixture is then concentrated in vacuo on a steam bath
2. additionThe dark-colored residue is diluted with water
3. extractionextracted with ether
4. washThe ether extracts are washed with water
5. dry with materialdried with anhydrous magensium sulfate
6. concentrationconcentrated in vacuo