反应详情

A solution of 5.31 g. of (±)-2-cyano-4-(5-acetoxy-2-hydroxy-3,4,6-trimethylphenyl)butan-2-ol in 60 ml. of methanol was cooled in an ice bath under N2. Sulfuric acid (3.8 ml.) was added over 5 minutes. The light yellow solution was stirred at 23° for 72 hours and then at reflux for 5 hours, cooled, poured into ice-H2O and filtered. The solid was washed with H2O and crystallized from ether-30°-60° petroleum ether to give (±)-2-cyano-6-hydroxy-2,5,7,8-tetramethylchroman as a white needle, m.p. 152.5°-153° .

1. temperatureat reflux for 5 hours
2. temperaturecooled
3. filtrationfiltered
4. washThe solid was washed with H2O
5. customcrystallized from ether-30°-60° petroleum ether