反应详情

温度

90 °C

21.9 parts of 2-benzyloxy-1,3-dichloro-propane, 59.1 parts of iso-propylamine and 59.1 parts of water were added to an autoclave, and the mixture was heated at 90° C. for 48 hours with agitation. The reaction mixture was cooled and treated in the same manner as in Example 29, followed by distillation under reduced pressure. As a result 17.4 parts of 3-benzyloxy-1-(iso-propyl)azetidine boiling at 105° - 107° C. under 2 mm Hg were obtained. The yield was 85%. The results of infra-red spectrum analysis and nuclear magnetic resonance analysis of the product are as follows:

1. temperatureThe reaction mixture was cooled
2. additiontreated in the same manner as in Example 29
3. distillationfollowed by distillation under reduced pressure