HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 328909Generated: October 26, 2026
Hydrochloric Acid → 1-(6'-Methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride
https://huagongshe.com/reaction/328909
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| Reactant | 6-methoxy-1-naphthol | HCID 11008416 | — |
| Product | 1-(6'-Methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride | HCID 20517328 | 57.5% |
Reaction Steps
A mixture of 9.5 parts of 6-methoxy-1-naphthol, 5.8 parts of 1-(iso-propyl)-3-azetidinol and 0.3 part of potassium hydroxide was heated under nitrogen gas at 140° C. for 8 hours with agitation. The reaction mixture was treated in the same manner as in Example 1, and when the resulting hydrochloride was recrystallized from iso-propyl alcohol, there was obtained 17.7 parts of 1-(6'-methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride melting at 165° - 167° C. The yield was 57.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04018824 |
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| Source dataset | uspto-grants-1977_04 |
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| ORD ID | ord-d56827fc3bf84ff481daf1a4e2331829 |
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| Source note | uspto-grants-1977_04 |
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