3-Aminophenol → HCID 12666331, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 21.8 parts of m-aminophenol, 22 parts of 1-(tert.-butyl)-3-azetidinol and 0.7 part of potassium hydroxide was heated under nitrogen gas at 140° C. for 8 hours with agitation. The reaction mixture was cooled and treated in the same manner as in Example 39. Recrystallization from benzene gave 17.2 parts of 1-(3'-aminophenoxy)-3-(tert.-butylamino)-2-propanol in the form of colorless needles melting at 105° - 106° C. The yield was 42.3%. The results of infra-red spectrum analysis are as follows:

Provenance & Evidence