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Trimethyl orthoformate → 4-(2-Carboxyethenyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethyl orthoformate | HCID 9005 | — |
| 反応物 | 2-Propenoic acid, 3-(4-formylphenyl)- | HCID 98077 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(2-Carboxyethenyl)benzoic acid | HCID 89196 | — |
反応手順
A solution of 37.0 g of 4-formylcinnamic acid in 22 ml of trimethyl orthoformate and 600 ml of methanol was heated under reflux for 17 hrs. with stirring. At the end of this time, 100 ml of methanol was added and the reaction mixture was heated under reflux for an additional 5 hrs. and then allowed to cool to room temperature. The precipitate was collected, washed with methanol and dried at 75°-80° overnight to give 7.36 g of 4-carboxycinnamic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04018884 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-409c1f137b564fdaa391c6b4c6a40315 |
| 出典メモ | uspto-grants-1977_04 |