Sulfuric Acid → HCID 21440157, compound

Participants

Reaction Steps

To a solution of 3-amino-4-benzoyl-5--nitrobenzoic acid (100 g) in a mixture of conc. sulfuric acid (875 ml) and water (280 ml) is dropwise added a solution of sodium nitrite (45.0 g) in water (280 ml), while stirring at -5° C to 0° C. After additional stirring at -5° C to 0° C for about 15 minutes, the resulting diazoniumsolution is heated on a steam bath for 2-3 hours until the nitrogen evolution has ceased. After cooling, the resulting precipitate is collected by filtration and washed with water. After drying and recrystallization twice from aqueous ethanol, 4-benzoyl-3-hydroxy-5-nitrobenzoic acid is obtained as a monohydrate with a melting point of 264° -266° C.

Provenance & Evidence