HCID 131710721, compound → HCID 12409672, compound

Participants

Reaction Steps

To a solution of 4-benzoyl-3-hydroxy-5-sulfamylbenzoic acid hemihydrate (3.21 g) in 0.50 N NaOH (40.0 ml), benzyl bromide (1.2 ml) is added and the mixture is stirred at room temperature for 5 hours. The mixture is left in a refrigerator for about 16 hours, and the separated sodium 4-benzoyl-3-benzyloxy-5-sulfamylbenzoate is collected by filtration and washed with a small amount of ice-cold water. The salt is dissolved in 1 N sodium hydroxide (30 ml) and the solution is added to ice-cold 1 N acetic acid (35 ml). The resulting precipitate is collected by filtration and washed with water. After drying in vacuo in the presence of P2O5, 4-benzoyl-3-benzyloxy-5-sulfamylbenzoic acid is obtained. The material is identical (IR, analysis) with the material prepared as in Example 40.

Provenance & Evidence