HCID 53711917, compound → HCID 21440779, compound

HRID 328997Notes

Reaction equation

HRID 328997 reaction equation
[C:1]1([C:7]([CH:16]2[CH2:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:17]2)=[CH:8][CH2:9][CH2:10][N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd]>[C:1]1([CH:7]([CH:16]2[CH2:17][C:18]3[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:24]2)[CH2:8][CH2:9][CH2:10][N:11]([CH2:12][CH3:13])[CH2:14][CH3:15])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 53711917HCID 53711917, compound

Product 1

HCID 21440779HCID 21440779, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 23.5 g. of 1-phenyl-1-(2-indanyl)-4-diethylamino-1-butene in 375 cc. of 95 percent (v/v) ethanolbenzene was stirred while 1.5 g. of 5 percent palladium on carbon was added in one portion. The reaction mixture was stirred for 6 hours at 24° C. under a hydrogen gas atmosphere at 60 p.s.i. After filtering off the hydrogenation catalyst, the filtrate was concentrated to dryness under reduced pressure to provide 1-phenyl-1-(2-indanyl)-4-diethylaminobutane.

Workup

  1. stirringThe reaction mixture was stirred for 6 hours at 24° C. under a hydrogen gas atmosphere at 60 p.s.i
  2. filtrationAfter filtering off the hydrogenation catalyst
  3. concentrationthe filtrate was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-0bcc19245332469e947e3af9f33c0760
Source dataset
uspto-grants-1977_04
Patent number
US04018897

Reaction notes

Loading…