HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → HCID 21441102, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(Bromomethyl)pyridine | HCID 564209 | — |
| Reactant | N-(2-Aminoethyl)formamide | HCID 13561311 | — |
| Reactant | HCID 21441099 | HCID 21441099 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21441102 | HCID 21441102 | — |
Reaction Steps
A mixture of N-formyl-N-(2-pyridylmethyl)ethylene-diamine (prepared by adding sodium hydride to N-formylethylenediamine in dry dimethyl formamide, then reacting with 2-bromomethylpyridine at room temperature) and methyl isocyanate in dry chloroform is heated in a pressure vessel at 100° for 18 hours to give after cooling and removing the solvent N-methyl-N'-[2-((N"-formyl-N"-2-pyridylmethyl)amino)ethyl]urea. Acid hydrolysis by the procedure of Example 4 gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04018928 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-9995bf78c17647adb701859ea5a7aa2b |
| Source note | uspto-grants-1977_04 |