HuagongsheHuagongshe Chemistry Print Report · For research reference only
10-(3-Chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine → 2-Trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 10-(3-Chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine | HCID 74294 | — |
| Reactant | 4-(4-Piperidyloxy)-butanol | HCID 21440902 | — |
| Product | 2-Trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride | HCID 21440928 | 39% |
Reaction Steps
Using the procedure of Example XI, 49.7 g (0.145 mole) of 2-trifluoromethyl-10-(3-chloropropyl)-phenothiazine and 25.5 g (0.145 mole) of 4-(4-piperidyloxy)-butanol were reacted to obtain 29 g (39% yield) of 2-trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride in the form of white crystals melting at 67° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04018922 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-c91d8cc0d323414aa71221798c7b4f3f |
| Source note | uspto-grants-1977_04 |