Acetyl chloride → HCID 21440934, compound

HRID 329043Notes

Reaction equation

HRID 329043 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][CH:23]([O:26][CH2:27][CH2:28][CH2:29][OH:30])[CH2:22][CH2:21]3)[C:5]=2[CH:4]=1.[C:33](Cl)(=[O:35])[CH3:34]>>[F:32][C:2]([F:31])([F:1])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]3[CH2:21][CH2:22][CH:23]([O:26][CH2:27][CH2:28][CH2:29][O:30][C:33](=[O:35])[CH3:34])[CH2:24][CH2:25]3)[C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 218097HCID 218097, compound

Product 1

HCID 21440934HCID 21440934, compoundYield 49.2%

Procedure

Using the procedure of Example XXXV, 18.7 g (0.04 mole) of 2-trifluoromethyl-10-[3-(4-{3-hydroxypropoxy}-piperidino)-propyl]-phenothiazine (prepared in Example XVIII) and 3.14 g (0.04 mole) of acetyl chloride were reacted to obtain 10 g (49% yield) of 2-trifluoromethyl-10-[3-(4-{3-acetoxypropoxy}-piperidino)-propyl]-phenothiazine as a clear amber oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-aaf62e0d98134b2dbf231dd765142231
Source dataset
uspto-grants-1977_04
Patent number
US04018922

Reaction notes

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