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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 329071Generated: October 31, 2026

Methyl isothiocyanate → N-methyl-N'-[2-((4-chloro-2-methyl-5-pyrimidyl)methylthio)ethyl]thiourea

https://huagongshe.com/reaction/329071

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl isothiocyanateHCID 11167—
Reactant2-(3-Mercaptopropyl)isoindoline-1,3-dioneHCID 11020441—
Reactant2-(Chloromethyl)pyrimidineHCID 12877371—
ReactantN-methyl-N'-[3-(2-pyrimidylmethylthio)propyl]thioureaHCID 20557895—
ProductN-methyl-N'-[2-((4-chloro-2-methyl-5-pyrimidyl)methylthio)ethyl]thioureaHCID 20557890—

Reaction Steps

In the procedure of Example 1(i)(b) and (ii), using 2-chloromethylpyrimidine and 3-phthalimidopropanethiol as the starting materials, the product is N-methyl-N'-[3-(2-pyrimidylmethylthio)propyl]thiourea.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04018931
Source datasetuspto-grants-1977_04
ORD IDord-b47d3c4b59b84a64ae9f2c2f0ace9760
Source noteuspto-grants-1977_04