HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → (3,5-Dimethyl-1,2-thiazol-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Dimethyl-1,2-thiazole-4-carboxylic acid | HCID 23361810 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (3,5-Dimethyl-1,2-thiazol-4-yl)methanol | HCID 13842752 | — |
Reaction Steps
3,5-Dimethyl-4-isothiazolecarboxylic acid is converted to the ethyl ester and the ester is reduced with lithium aluminium hydride in tetrahydrofuran to give 4-hydroxymethyl-3,5-dimethylisothiazole. Using this hydroxymethyl compound as the starting material for the above process gives N-methyl-N'-[2-((3,5-dimethyl-4-isothiazolyl)methylthio)ethyl]thiourea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04018931 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-1a62e316f7194c65a482288a7ca8d821 |
| Source note | uspto-grants-1977_04 |