HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-[(2-Aminoethyl)thiomethyl]isoxazole hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Reactant | 3-(Chloromethyl)-1,2-oxazole | HCID 4913025 | — |
| Product | 3-[(2-Aminoethyl)thiomethyl]isoxazole hydrobromide | HCID 20550203 | — |
Reaction Steps
A solution of 3-chloromethylisoxazole (5.8 g.) and cysteamine hydrochloride (6.25 g.) in aqueous hydrobromic acid (48%, 100 ml.) was heated under reflux for 6 hours. Concentration in the presence of water and subsequently n-propanol, followed by recrystallisation of the residue from isopropyl alcohol-ethanol afforded 3-[(2-aminoethyl)-thiomethyl]isoxazole hydrobromide, m.p. 131°-133°. (Found: Br, 33.6; S, 13.7. C6H10N2OS.HBr requires: Br, 33.4; S, 13.4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04018931 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-072c02e041e1481bb01c440d5e568db3 |
| Source note | uspto-grants-1977_04 |