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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 329116Generated: October 30, 2026

Methyl isothiocyanate → N-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea

https://huagongshe.com/reaction/329116

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl isothiocyanateHCID 11167—
Reactant(2-Isothiocyanatoethyl)dimethylamineHCID 3853726—
ReactantN-(3-isothiazolylmethyl)ethylenediamineHCID 20557777—
ProductN-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thioureaHCID 20557944—

Reaction Steps

By the procedure of Example 40(a) (ii), N-(3-isothiazolylmethyl)ethylenediamine is reacted with 2-dimethylaminoethyl isothiocyanate to give N-(2-dimethylaminoethyl)-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea. Reacting with hydrobromic acid gives the hydrobromide salt.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04018931
Source datasetuspto-grants-1977_04
ORD IDord-74be08d09354478885c693f42caf7981
Source noteuspto-grants-1977_04