HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → HCID 2778117, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Acrylic Acid | HCID 6581 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)aniline | HCID 67574 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Product | HCID 2778117 | HCID 2778117 | — |
Reaction Steps
4-Chloro-3-trifluoromethyl aniline was converted to the diazonium salt with sodium nitrite and sulfuric acid and this was reacted with acrylic acid (Meerwein reaction) to give 4-chloro-3-trifluoromethyl cinnamic acid. This acid was hydrogenated, reduced with lithium aluminum hydride to the alcohol and reacted with phosphorus tribromide to give 3(4-chloro-3-trifluoromethylphenyl)propyl bromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE029196 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-650b2d6ae56e4be39d98974353fa95d6 |
| Source note | uspto-grants-1977_04 |