2,6-Dichloroaniline → HCID 178480764, compound

Participants

Reaction Steps

A mixture of 20.38 g (0.08m) of 7-chloro-3,4-dihydro-4-methyl-2-methylthio-5H-1,4-benzodiazepine5-one and 64.81 g (0.40m) of 2,6-dichloroaniline is stirred and heated to 225° for 11/2 hr. The reaction mixture is cooled to room temperature and crystallized from ether to give the crude product, 7-chloro-2-(2',6'-dichloroanilino)-3,4-dihydro-4-methyl-5H-1,4-benzodiazepine-5-one, m.p. (230) 240°-245°. Recrystallization from acetone-ether and from methanol-isopropanol gives white solid with m.p. 247°-249.5°.

Provenance & Evidence