t-Butyl 1-bromocyclopentanecarboxylate → 2-(1-t-Butoxycarbonylcyclopent-1-yloxyimino)-2-(fur-2-yl) acetic acid

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The dipotassium salt of 2-(fur-2-yl)-2-hydroxyiminoacetic acid (syn isomer) was generated under an atmosphere of dry nitrogen and alkylated with t-butyl 1-bromocyclopentanecarboxylate using the method of Preparation 2. The product was isolated by pouring into water, acidifying and extracting in the conventional manner, thereby yielding the title compound, m.p. 106.8°-107.3°; λmax (pH 6 buffer) 277.5 nm (ε 15,100); τ(d6 -DMSO) values include 8.03, 8.30 (m, cyclopentyl protons) and 8.63 (C(CH3)3).

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