HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3,4-Methylenedioxyphenylalanyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | (S)-2-Amino-3-(benzo[D][1,3]dioxol-5-YL)propanoic acid | HCID 12918717 | — |
| Reactant | N-Phenylglycyl chloride--hydrogen chloride (1/1) | HCID 13140662 | — |
| Product | 3,4-Methylenedioxyphenylalanyl chloride hydrochloride | HCID 86734216 | — |
Reaction Steps
The compound 3,4-methylenedioxyphenylalanine, Ber., 59, 2952 (1926), is treated with hydrogen chloride and phosphorous pentachloride in accordance with the procedure described by Hartcastle et al., J. Org. Chem., 31, 897 (1966) for the preparation of phenylglycyl chloride hydrochloride to yield 3,4-methylenedioxyphenylalanyl chloride hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04020060 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-2c6906adf7194110b7100c74188569f5 |
| Source note | uspto-grants-1977_04 |