HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzoic Acid → 5-(3-Chlorophenyl)-N-methyl-1,3,4-thiadiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzoic Acid | HCID 447 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(3-Chlorophenyl)-N-methyl-1,3,4-thiadiazol-2-amine | HCID 15277968 | — |
Reaction Steps
A well-stirred mixture of 125 g (0.8 mole) of 3-chlorobenzoic acid and 84 g (0.8 mole) of 4-methylthiosemicarbazide in 700 ml of dioxane was heated until the solution was homogeneous. Phosphorus oxychloride (123 g, 0.8 mole) was added dropwise to the resulting solution at a rate to maintain the dioxane at gentle reflux.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04020078 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-18289e23d0f945a08dbc233cdc067251 |
| Source note | uspto-grants-1977_04 |