Ethyl orthoformate → HCID 21439072, compound

HRID 329189Notes

Reaction equation

HRID 329189 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][NH2:13].[CH2:14](OC(OCC)OCC)C>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][N:6]3[CH:14]=[N:13][N:12]=[C:5]3[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 330442(6-chloroquinazolin-4-yl)hydrazine

Product 1

HCID 21439072HCID 21439072, compound

Procedure

A mixture of 155.7 gms. of 6-chloro-4-hydrazinoquinazoline and 3000 ml. of triethoxy methane is refluxed with stirring for 48 hours, and after filtering off the insoluble material, the filtrate is evaporated in vacuo to dryness and the residue recrystallized from ether to obtain 9-chloro-1,2,4-triazolo[4,3-c]quinazoline, m.p. 179°-182° C.

Workup

  1. additionA mixture of 155.7 gms
  2. filtrationafter filtering off the insoluble material
  3. customthe filtrate is evaporated in vacuo to dryness
  4. customthe residue recrystallized from ether

Sources & evidence

ORD record
ord-39d749a37ba34979b5f286dbab538bf1
Source dataset
uspto-grants-1977_04
Patent number
US04020083

Reaction notes

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