Triethylamine → HCID 54493867, compound

Participants

Reaction Steps

A mixture of 12.44 g of diethyl chlorothiophosphate, 6.67 g of triethylamine and 15 g of 2-cyclohexyloxy-4-hydroxy-5-cyano-thiazole was stirred for 3 days and then concentrated to dryness. The residue was added to water and the aqueous phase was extracted with ether. The ether phase was dried and evaporated to dryness. The residue was crystallized from pentane and then isopropyl ether to obtain 10 g of 2-cyclohexyloxy-4-diethoxythiophosphoryloxy-5-cyano-thiazole in the form of white crystals melting at 58° C.

Provenance & Evidence