Acetic Anhydride → HCID 178431810, compound

Participants

Reaction Steps

The oil obtained in Example 3, N-[2-cyclohexylthio)ethyl]-N-nitrosoalanine, is treated with 54 parts of acetic anhydride and allowed to stand for 4 days at room temperature. After that time, the reaction mixture is added to 500 parts of water and extracted with methylene chloride. The organic extracts are washed with water and aqueous sodium bicarbonate, dried over anhydrous sodium sulfate and evaporated to dryness. The oil remaining is crystallized from ether by seeding and cooling. The crystalline material is recovered by filtration and dried to afford pure 3-[2-(cyclohexylthio)ethyl] -4-methylsydnone, melting at about 82°-83°. That compound is represented structurally by the following formula ##STR7##

Provenance & Evidence