Water → HCID 178431809, compound

Participants

Reaction Steps

The N-[2-(1-adamantylthio)ethyl]-N-nitrosoalanine prepared in Example 6 is dissolved in 163 parts of acetic anhydride, then allowed to stand at room temperature for 24 hours. The solution is heated briefly to 65° on a steam bath and allowed to cool to room temperature. Then the solution is added to 1000 parts of water and stirred for 3 hours. The solid which forms is collected by filtration, washed successively with water, and saturated sodium bicarbonate and water, and dried. Recrystallization of the solid from methylene chloride-ether affords pure 3-[2-(1-adamantylthio)ethyl] 4-methylsydnone, melting at about 92°-93° and represented by the following structural formula ##STR8##

Provenance & Evidence