HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3,3-dimethylbutanoic Acid → 2-tert-butyl-N-[2-(1-adamantylthio)ethyl-]glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3,3-dimethylbutanoic Acid | HCID 184251 | — |
| Reactant | 2-(Adamantan-1-ylthio)ethanamine | HCID 303799 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 2-tert-butyl-N-[2-(1-adamantylthio)ethyl-]glycine | HCID 21439033 | — |
Reaction Steps
A mixture of 42.3 parts of 2-(1-adamantylthio)ethylamine, 10.8 parts of sodium methoxide, 39.0 parts of 2-bromo-2-tert-butyl acetic acid and 315 parts of tert-butanol is refluxed, under a nitrogen atmosphere, for 5 hours. The product is recovered in the manner described in Example 5 to yield 2-tert-butyl-N-[2-(1 -adamantylthio)ethyl-]glycine, melting at about 220°-230°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04020079 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-49abff0ab6134960a4a17e04072b4618 |
| Source note | uspto-grants-1977_04 |