Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic anhydride → Pga1
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic anhydride | HCID 9845 | — |
| 반응물 | Alprostadil | HCID 5280723 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Pga1 | HCID 5281912 | — |
반응 단계
Alternately, the PGE1 -type compound is transformed to a bis-trifluoroacetate, for example by reaction with trifluoroacetic anhydride in the presence of pyridine in a solvent at 0° to 5° C., and thereafter contacted with a low-boiling alcohol (preferably b.p. below 110° C.) with a tertiary amine to form a PGA1 -type compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04020097 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-bbff630be3b54a90b997732bb985644d |
| 출처 메모 | uspto-grants-1977_04 |