Pentachlorophenol → HCID 54166524, compound

Participants

Reaction Conditions

Reaction Steps

3-Tritylthiopropionic acid [1.0 g, 2.87 mmoles, described by R. C. Hiskey and M. A. Harpold, J. Org. Chem., 33, 559 (1968)] is dissolved in dry tetrahydrofuran (25 ml) and pentachlorophenol (0.765 g, 2.87 mmoles) is added. The mixture is cooled to 0° C, dicyclohexylcarbodiimide (0.596 g, 2.87 mmoles) is added and the reaction is stirred for 1 hr at 0° C and 1 hr at 25° C. The reaction mixture is then cooled to 0° C, filtered and the filtrate is evaporated under reduced pressure. The residue is crystallized from ethyl acetate to give the title compound, mp 154°-156° C.

Provenance & Evidence