HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitrobenzaldehyde → HCID 68121035, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-ethoxy-3-oxobutyrate | HCID 3016245 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68121035 | HCID 68121035 | 70% |
Reaction Steps
15 g of 3-nitrobenzaldehyde, 18 g. of γ-ethoxyacetoacetic acid ethyl ester and 13 g of β-aminocrotonic acid ethyl ester are heated in 60 ml of ethanol for about 5 hours, the mixture is cooled and the product is filtered off and rinsed with cold ethanol. 2-Ethoxymethyl-6-methyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained, in the form of light yellow crystals of melting point 120°-122° C, in a yield of 70% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04020178 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-964968badd824995b0e422e523a87227 |
| Source note | uspto-grants-1977_04 |