HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-(Trifluoromethyl)benzaldehyde → HCID 68120304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-(Trifluoromethyl)benzaldehyde | HCID 123067 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-ethoxy-3-oxobutyrate | HCID 3016245 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68120304 | HCID 68120304 | 55% |
Reaction Steps
7.4 g of 2-trifluoromethylbenzaldehyde, 17.4 g of γ-ethoxyacetoacetic acid ethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 80 ml of ethanol are heated under reflux overnight, the mixture is cooled and 2-ethoxymethyl-6-methyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of white-yellow crystals of melting point 112° C, in a yield of 55% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04020178 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-3b964bc05884436e939089f229b19dfa |
| Source note | uspto-grants-1977_04 |