HCID 22759337, compound → HCID 22759307, compound

HRID 329286Notes

Reaction equation

HRID 329286 reaction equation
[C:1]([C:4](C(OCC)=O)([CH2:16][C:17]#[C:18][CH:19]([O:29]C(=O)C)[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])(=[O:3])[CH3:2].C(C(C(OCC)=O)(CCCC(OC(=O)C)COC1C=CC(F)=CC=1)CC#CCCCC(OC)=O)(=O)C>>[C:1]([CH:4]([CH2:16][C:17]#[C:18][CH:19]([OH:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 22759337HCID 22759337, compoundHCID 22759338HCID 22759338, compound

Product 1

HCID 22759307HCID 22759307, compound

Procedure

The synthesis of this compound is carried out by the basic hydrolytic procedure described in Example 4, Step D except that an equivalent amount of ethyl 8-acetyl-8-ethoxycarbonyl-12-acetoxy-13-(4-fluorophenoxy)-10-tridecynoate is substituted for the methyl 8-acetyl-8-ethoxycarbonyl-12-acetoxy-13-(4-fluorophenoxy)-5-tridecynoate of Example 4, Step D. The product is purified by column chromatography on silica gel and is a light yellow viscous oil.

Workup

  1. customThe synthesis of this compound
  2. customThe product is purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-e7de5e4d37f84edb8b7c4de7adb6ce58
Source dataset
uspto-grants-1977_04
Patent number
US04020177

Reaction notes

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