HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethylsulfanyl-3-methoxy-3-methyl-but-1-yne → 2-(2-ethylsulfanyl-1-methoxy-1-methyl-ethyl)-1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethylsulfanyl-3-methoxy-3-methyl-but-1-yne | HCID 58979604 | — |
| Reactant | N-[2-Iodo-4-nitro-5-(trifluoromethyl)phenyl]methanesulfonamide | HCID 58979620 | — |
| Product | 2-(2-ethylsulfanyl-1-methoxy-1-methyl-ethyl)-1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indole | HCID 11626339 | — |
Reaction Steps
This compound was prepared using the standard Sonagashira procedure as described in General Procedures Example C. The starting material was N-(2-iodo-4-nitro-5-trifluoromethyl-phenyl)-methanesulfonamide (0.34 g, 0.82 mmol) and 4-ethylsulfanyl-3-methoxy-3-methyl-but-1-yne (0.13 g, 0.82 mmol), reacted to yield the title compound as a yellow film.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427682B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-d38bdd28172f4dbcb04b810c551498b3 |
| Source note | uspto-grants-2008_09 |