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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 32931Generated: October 29, 2026

4-Ethylsulfanyl-3-methoxy-3-methyl-but-1-yne → 2-(2-ethylsulfanyl-1-methoxy-1-methyl-ethyl)-1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indole

https://huagongshe.com/reaction/32931

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Ethylsulfanyl-3-methoxy-3-methyl-but-1-yneHCID 58979604—
ReactantN-[2-Iodo-4-nitro-5-(trifluoromethyl)phenyl]methanesulfonamideHCID 58979620—
Product2-(2-ethylsulfanyl-1-methoxy-1-methyl-ethyl)-1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indoleHCID 11626339—

Reaction Steps

This compound was prepared using the standard Sonagashira procedure as described in General Procedures Example C. The starting material was N-(2-iodo-4-nitro-5-trifluoromethyl-phenyl)-methanesulfonamide (0.34 g, 0.82 mmol) and 4-ethylsulfanyl-3-methoxy-3-methyl-but-1-yne (0.13 g, 0.82 mmol), reacted to yield the title compound as a yellow film.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07427682B2
Source datasetuspto-grants-2008_09
ORD IDord-d38bdd28172f4dbcb04b810c551498b3
Source noteuspto-grants-2008_09