Water → HCID 14129277, compound

HRID 329338Notes

Reaction equation

HRID 329338 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][CH:11]=[N:10]1.[Br:19]Br.O>C(O)(=O)C>[Br:19][C:12]1[CH:11]=[N:10][N:9]([C:3]2[C:4]([Cl:8])=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:13]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 14129276Ethyl 1-(2,6-dichlorophenyl)-1H-pyrazole-5-carboxylate

Product 1

HCID 14129277HCID 14129277, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

14.3 g of ethyl 1-(2,6-dichlorophenyl)-pyrazole-5-carboxylate from Example 4 were dissolved in 100 ml of glacial acetic acid, 10 g of Na acetate were added, and 4.5 g of bromine were added dropwise at room temperature. After 60 hours, the reaction mixture was poured into 1 liter of water, washed with water and recrystallized from ethanol. Yield: 8.2 g Melting point: 62°-65° C.

Workup

  1. washwashed with water
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-ea5228032cd54136b1dddf3cbd92d683
Source dataset
uspto-grants-1990_01
Patent number
US04891057

Reaction notes

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