Hydrochloric Acid → HCID 86743635, compound

Participants

Reaction Steps

Hydrogen chloride gas Was passed through a solution of 1-[(2β, 3α, 5α, 16β, 17α)-3-(acetyloxy)-17-(1-oxobutoxy)-2-(1-piperidinyl)-androstan-16-yl]-1-methylpiperidinium bromide, (0.5 g) in dichloromethane (40 ml), then the solution was evaporated to give a froth. The product was dissolved in acetone and diethyl ether was added to precipitate an amorphous solid, Which Was filtered off and washed with ether. The solid was heated under reflux in acetone to give 1-[(2β, 3α, 5α, 16β, 17α)-3-(acetyloxy)-17-(1-oxobutoxy)-2-(1-piperidinyl)-androstan-16-yl]-1-methylpiperidinium bromide hydrochloride as prisms (0.45 g), m.p. 220°-228° C., [α]D20 =+57.2° (c 1.32 in CHCl3).

Provenance & Evidence