7-Nitro-3-(2-[4-nitrophenoxy]ethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine → 7-Amino-3-(2-[4-aminophenoxy]ethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine

Participants

Reaction Steps

7-Nitro-3-(2-[4-nitrophenoxy]ethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine (0.42 g) was stirred at room temperature under a hydrogen atmosphere [344.7 kPa (50 p.s.i.)] in ethyl acetate containing 5% Pd/C for 4 hours. The catalyst was then removed by filtration and the filtration evaporated in vacuo to give the title compound as an oil, which was used directly without further purification, yield 0.3 g.

Provenance & Evidence