HCID 19872043, compound → HCID 19872041, compound

HRID 329374Notes

Reaction equation

HRID 329374 reaction equation
[N+:1]([C:4]1[CH:30]=[CH:29][C:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][NH:15][C:16](=[O:28])[C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][C:18]=3[O:26][CH3:27])[CH2:11][CH2:12][C:6]=2[CH:5]=1)([O-])=O>C(O)C.CO>[NH2:1][C:4]1[CH:30]=[CH:29][C:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][NH:15][C:16](=[O:28])[C:17]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][C:18]=3[O:26][CH3:27])[CH2:11][CH2:12][C:6]=2[CH:5]=1

Participants

3

Reactant 1

HCID 19872043HCID 19872043, compound

Product 1

HCID 19872041HCID 19872041, compound

Reagents, catalysts & solvents 1

HCID 18681192Ethanol, mixt. with methanolSolvent

Procedure

7-Nitro-3-(2-[2-methoxy-4-nitrobenzamido]ethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine (0.52 g) was stirred under a hydrogen atmosphere [344.7 kPa (50 p.s.i.)] in an ethanol/methanol (1:1) solution at room temperature for 3 hours. The catalyst was then removed by filtration and the filtrate evaporated in vacuo to give the title compound as a foam, yield 0.42 g, which was used directly without further purification.

Workup

  1. customThe catalyst was then removed by filtration
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-991a0d52c433478e88bee8c7ba42eb1c
Source dataset
uspto-grants-1990_01
Patent number
US04891372

Reaction notes

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