Water → 2-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one

Participants

Reaction Steps

206 g (0.83 mol) of 1-(3,5-di-tert.butyl-4-hydroxyphenyl)ethanone are dissolved in 415 ml of methylene chloride while stirring, the mixture is heated to boiling, and 144 g (0.9 mol) of bromine are added dropwise over the course of 30 minutes. The mixture is then refluxed for a further 2 hours and cooled, 400 ml of water are added, and the organic phase is separated off and dried over sodium sulfate. After the solvent had been removed under reduced pressure, the solid crude product obtained was recrystallized from 540 ml of methylcyclohexane.

Provenance & Evidence