Hydrogen Bromide → HCID 14210976, compound

Participants

Reaction Steps

A solution of 82.5 g (0.4 mol) of 1-(5-tert.butyl-3-methyl-hydroxyphenyl)-ethanone in 360 ml of chloroform was added dropwise while stirring to a suspension, heated to boiling, of 179 g (0.8 mol) of copper(II) bromide in 360 ml f ethyl acetate. The mixture was subsequently refluxed for 4 hours until the evolution of hydrogen bromide was complete. After the mixture had been cooled to room temperature, the copper salts were filtered off under suction, the filter residue was washed repeatedly with ethyl acetate, the filtrate was evaporated under reduced pressure, the solid residue was recrystallized from cyclohexane.

Provenance & Evidence