L-Malic Acid → HCID 131716221, compound

Participants

Reaction Steps

37.4 g (0.279 mol) of L-(-)-malic acid are added to a solution of 41.06 g (0.279 mol) of (R), (S)-1-(4-vinylphenyl)-ethylamine in 250 ml of methanol at 0° C. After 15 hours, the precipitated crystals (31.0 g) are filtered off under suction, and the mother liquor is evaporated down in vacuo until crystallization begins again. A further 15 g of product are obtained. The crystal fractions are combined and recrystallized twice, in each case from 250 ml of methanol, with the addition of about 50 mg of di-tert-butyl-p-cresol. Yield: 15.2 g of white crystalline powder, [α]D20 =+2.10° (H2O, c=0.95).

Provenance & Evidence