6-Methyl-2-pyridinecarboxaldehyde → HCID 86743636, compound

Participants

Reaction Steps

A solution of 1.69 g (13.9 mmol) of 6-methylpyridine-2-carbaldehyde, 2.05 g (13.9 mmol) of (R)-1-(4-vinylphenyl)-ethylamine and 25 ml of ethanol is heated under reflux for 1 hour. The solvent is then distilled off under about 3 kPa, and the residue is distilled in a bulb tube furnace at 170° C. and under 0.11 Pa. 3.3 g (88% of theory) of an oil are obtained, which crystallises at room temperature. Melting point: about 25° C., [α]D20 =21.6° (c=1.036, chloroform). Elemental analysis: Found: C 81.71; H 7.25; N 11.02%; Calculated for C17H18N2 (250.35): C 81.56; H 7.25; N 11.19%.

Provenance & Evidence