Acetic Anhydride → 5-Acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride

HRID 329430Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5]([C:9]([OH:11])=O)=[N:6][C:7]=1[CH3:8].[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([O:1][C:2]1[CH:3]=[C:4]2[C:12](=[O:13])[O:14][C:9](=[O:11])[C:5]2=[N:6][C:7]=1[CH3:8])(=[O:17])[CH3:16]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 198721365-Hydroxy-6-methylpyridine-2,3-dicarboxylic acid

Product 1

HCID 137994445-Acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride

Conditions

Temperature: 140 °C

Procedure

A suspension of 1.0 g (5.1 mmol) 5-hydroxy-6-methylpyridine-2,3-dicarboxylic acid and 5 ml acetic acid anhydride are heated at a bath temperature of 140° C. until a clear solution is produced. After compressing, the desired product is obtained.

Workup

customis produced

Sources & evidence

ORD record: ord-9986de996fbd4675b5aaf29af435d134
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04891428

Reaction notes

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