p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

Participants

Reaction Steps

In 130 ml of acetone was dissolved 3.9125 g of Compound (21) obtained in Reference Example 21. To the solution was added, under ice-cooling, 1.482 g of p-toluenesulfonic acid monohydrate, followed by stirring at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. To the residue was added 150 ml of ether to cause crystallization. Resulting crystals were collected by filtration and washed with 50 ml of ether to thereby obtain 3.211 g of p-toluene sulfonate of (3R,4R)-3-amino-4-tritylthio-2-azetidinone as white crystals.

Provenance & Evidence