Phthalic Anhydride → HCID 15051991, compound

Participants

Reaction Steps

This compound was prepared in a manner analogous to that of Example 1, Step C, using 2.0 grams (0.0067 mole) of 2-[(4-amino-2-bromophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone and 1.0 gram (0.0067 mole) of phthalic anhydride in 50 ml of tetrahydrofuran. The reaction mixture was concentrated under reduced pressure to a residual solid. The solid was recrystallized from ethyl acetate-hexane to yield 2.8 grams of 2-[[2-bromo-4-[(2-carboxyphenyl)carbonylamino]phenyl]methyl]-4,4-dimethyl-3-isoxazolidinone, m.p. 177° C., dec.

Provenance & Evidence