Acetic Anhydride → HCID 178502586, compound

HRID 329577Notes

Reaction equation

HRID 329577 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:3]=1[C:14]([O:16][CH3:17])=[S:15].[C:18](OC(=O)C)(=[O:20])[CH3:19]>C(O)(=O)C>[C:18]([NH:1][C:2]1[NH:6][N:5]=[C:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:3]=1[C:14]([O:16][CH3:17])=[S:15])(=[O:20])[CH3:19]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178502585HCID 178502585, compound

Product 1

HCID 178502586HCID 178502586, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

70.5 g (0.27 mol) Methyl 5-amino-3-benzylthiopyrazole-4-carboxylate was dissolved at 80° C. in 135 ml glacial acetic acid and treated with 27.75 g (0.27 mol) acetic anhydride. The solution was heated under reflux for 7 hours and concentrated. The residue was recrystallised from ether, the crystals suction filtered, washed with ether and dried.

Workup

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 7 hours
  3. concentrationconcentrated
  4. customThe residue was recrystallised from ether
  5. filtrationthe crystals suction filtered
  6. washwashed with ether
  7. customdried

Sources & evidence

ORD record
ord-b23cb7de40d24c38ae3ac57960e8c999
Source dataset
uspto-grants-1990_01
Patent number
US04892576

Reaction notes

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