HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 17beta-Acetoxy-1alpha-methyl-17alpha-n-propyl-5alpha-androstan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Rosterolone | HCID 71232 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 17beta-Acetoxy-1alpha-methyl-17alpha-n-propyl-5alpha-androstan-3-one | HCID 13020886 | — |
Reaction Steps
1.5 g of 17β-hydroxy-1α-methyl-17α-n-propyl-5α-androstan-3-one is allowed to stand at room temperature in 6 ml of pyridine with 3 ml of acetic anhydride for 16 hours, after the addition of 75 mg of 4-dimethylaminopyridine. After the mixture has been precipitated into ice water and recrystallized from hexane, 1.3 g of 17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3-one is obtained, m.p. 128°-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892867 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-a3675ffaa37d4bbda7cd09c424005b44 |
| Source note | uspto-grants-1990_01 |