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To 2.34 g (24.1 mmol) of potassium thiocyanate in 30 ml of acetone was added 2.32 ml (20.0 mmol) of benzoyl chloride. The mixture was then refluxed for 15 min, cooled to r.t., and 3.16 g (16.3 mmol) of 2,6-diethyl-4-nitroaniline obtained from step C was added. The mixture was then refluxed for 15 min, cooled to r.t., and poured into 200 ml of ice-water. The precipitate was collected and washed with water, then dissolved in a solution comprising 0.70 g (18 mmol) of sodium hydroxide in 5 ml of water and 50 ml of ethanol. The solution was refluxed for 1 hr, cooled to r.t., poured into icewater, then the precipitate was collected, washed with water several times, and dried. The solids were then triturated with ethyl acetate to yield 2.44 g (59.2%) of product. NMR (CDCl3, d6 -DMSO):δ 1.30 (t, 6H), 2.74 (q, 4H), 6.9 (b, 2H), 7.98 (s, 2H), 9 (b, 1H).

1. temperatureThe mixture was then refluxed for 15 min
2. temperatureThe mixture was then refluxed for 15 min
3. temperaturecooled to r.t.
4. customThe precipitate was collected
5. washwashed with water
6. temperatureThe solution was refluxed for 1 hr
7. temperaturecooled to r.t.
8. additionpoured into icewater
9. customthe precipitate was collected
10. washwashed with water several times
11. customdried
12. customThe solids were then triturated with ethyl acetate