反应详情

To a solution of 33.9 g 1-bromo-3,3,3-trifluoro-2-propanone in 300 ml of absolute ethanol are added 28.6 g 4-methyl-1-piperazinylthiocarboxamide. The mixture is refluxed for 4 hours, evaporated to dryness and the residue partitioned between ethyl ether and aqueous NaOH. The ether phase is washed, dried and evaporated, whereby the title compound is obtained, m.p. 62° (ethyl acetate/hexane).

1. temperatureThe mixture is refluxed for 4 hours
2. customevaporated to dryness
3. customthe residue partitioned between ethyl ether and aqueous NaOH
4. washThe ether phase is washed
5. customdried
6. customevaporated