HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl bromide → N-2-Propynyl-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-(m-Acetamidophenyl)-1,2,4-triazolo[4,3-b]pyridazine | HCID 7532146 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-2-Propynyl-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide | HCID 15595657 | — |
Reaction Steps
A mixture of 3.0 g of N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide, 0.6 g of sodium hydride (50% in oil), 250 ml of dimethylformamide and 1.38 ml of propargyl bromide was reacted as described in Example 5, giving 1.77 g of the desired product as orange crystals, mp 195°-198° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892873 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-009573c22e4f4b7cbf5b05d9a84045f1 |
| Source note | uspto-grants-1990_01 |